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Houston Astros vs Pittsburgh Pirates (MLB). Sep 10 Houston Astros vs Pittsburgh Pirates (MLB). Sep 11 Houston Astros vs Pittsburgh Pirates (MLB). Sep 12 Houston Astros vs Chicago Cubs (MLB). Sep 13 Houston Astros vs Chicago Cubs (MLB). Sep 14 Houston Astros vs Chicago Cubs (MLB). Sep 23 Houston Astros vs Cincinnati Reds (MLB). Sep 24 Houston Astros vs Cincinnati Reds (MLB). Sep 25 Houston Astros vs Cincinnati Reds (MLB). Sep 26 Houston Astros vs Atlanta Braves (MLB). Sep 27 Houston Astros vs Atlanta Braves (MLB). Sep 28 Houston Astros vs Atlanta Braves (MLB).